Lutein, Zeaxanthin, and meso-Zeaxanthin Interventions against Ocular Disease
Lutein, zeaxanthin , and meso-zeaxanthin as the unique three carotenoids of human macula. The lutein and
zeacanthin can be get from our common dietary supplement nutrition such as the green vegetable, yellow
and organge vegetable and fruit, but the meso-zeaxanthin is rarely getting from dietary foods and it must
be getting through the metabolic transformations after taking the carotenoids to be the formed of macula.
Much of studies like epidemiological and many clinical trials such as AREDS2 make much attention to the
three carotenoids ( lutein, zeaxanthin, meso-zeaxanthin) strong functional benifits on the ocular health which
can get through from the diets supplements daily. But these basic science and clinical research fundamentally
recommended for the age-related macular degeneration and other eye diseases interventions against by
nutritional are unacceptable by clinicians and researchers.
From the study and researchers from Dr Paul S. Bernstein team which make the study and examine from the
chemistry, biophysics and physiolygy of these three carotenoids of yellow pigments that mainly concentrated
in the macula lutea through the means of high-affinity binding proteins and specialized transport and metabolic
proteins where they play important roles as short-wavelength (blue) light-absorbers and localized, efficient
antioxidants in a region at high risk for light-induced oxidative stress. And then they use the clinical evidence
which mainly in normal eyes to support their functional effects of these three carotenoids for their strong action
against the ocular disease from infancy to old age.
Although those clinical evidence show from a comprehensive review from each sides of chemistry, biochemistry,
biophysics and cinical studies to support the dietary supplement for the three carotenoids can cure the ocular
diseases. And further studies in these fields of inquiry should provide evidence-based guidance on nutritional
supplementation with lutein, zeaxanthin, and meso-zeaxanthin throughout a person's lifetime.